The platform technology of IOTA NanoSolutions Limited
is a revolution in the use and formulation of insoluble organic materials.
Nanodispersions of poorly soluble biocides, fluorescers, OTC and Rx pharmaceuticals,
dyes, flavours and fragrances, agrochemicals, nutraceuticals, sunscreens,
polymers, preservatives, insect repellents, bleaches, surface modifiers and
food ingredients have all been produced, and a number of these are currently
being evaluated by partners. The IOTA NanoSolutions platforms may be used
in any industry sector where poor solubility poses formulation constraints
and impairs the performance of product ingredients.
The novel nanodispersions are potentially patentable and often show superior in-use performance over solutions, emulsions or larger conventional particle dispersions (>1 micron). Crucially, organic nanodispersions have numerous benefits over inorganic nanoparticles, particularly as they are non-persistent as particles in the environment.
IOTA NanoSolutions’ technologies may potentially have a significant contribution to the reduction of the amount of organic solvents used in products, the extension of current active ingredient life-cycles, the acceleration of new chemical entity discovery and the broadening of patent protection for key proprietary materials.
A number of case studies exemplifying possible applications of the IOTA NanoSolutions technologies are highlighted below. In all cases, the use of the IOTA NanoSolutions technologies has produced nanodispersions which have been evaluated under realistic product conditions.
• Poorly soluble pharmaceutical actives: Increased/controlled speed of dissolution leading to improved delivery
• Enhanced activity of poorly soluble biocides: Lower MIC for nanodispersions
• Aqueous formulations of hydrophobic fluorescers: Enhanced deposition from water
The novel nanodispersions are potentially patentable and often show superior in-use performance over solutions, emulsions or larger conventional particle dispersions (>1 micron). Crucially, organic nanodispersions have numerous benefits over inorganic nanoparticles, particularly as they are non-persistent as particles in the environment.
IOTA NanoSolutions’ technologies may potentially have a significant contribution to the reduction of the amount of organic solvents used in products, the extension of current active ingredient life-cycles, the acceleration of new chemical entity discovery and the broadening of patent protection for key proprietary materials.
A number of case studies exemplifying possible applications of the IOTA NanoSolutions technologies are highlighted below. In all cases, the use of the IOTA NanoSolutions technologies has produced nanodispersions which have been evaluated under realistic product conditions.
• Poorly soluble pharmaceutical actives: Increased/controlled speed of dissolution leading to improved delivery
• Enhanced activity of poorly soluble biocides: Lower MIC for nanodispersions
• Aqueous formulations of hydrophobic fluorescers: Enhanced deposition from water
