Enhanced Bioactivity

Many biologically active materials have inherently low solubility in water. The hydrophobic nature of, for example, antimicrobials, fungicides, insecticides, and antiparasitic agents is often a factor contributing to the materials activity. It is this combination of hydrophobicity and activity that leads to formulation issues. The technologies of IOTA NanoSolutions can overcome this problem through the formation of nanodispersions. The data below compares the activity (measured as the minimum inhibitory concentration - MIC) of an ethanol/water solution and an aqueous nanodispersion of the same commercial antimicrobial.



IOTA NanoSolutions' dispersions show enhanced activity. In this example, the aqueous nanodispersion has an MIC approximately 1/8th of the concentration of the dissolved ethanol/water solution against a gram positive bacterium.

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