IOTA NanoSolutions Limited is a nanomaterials engineering
company specialising in the delivery and formulation of poorly soluble ingredients.
In so doing IOTA NanoSolutions’ technologies can help overcome many
of the factors that prevent the use and full value-realisation of many poorly
soluble actives. IOTA NanoSolutions has actively developed novel generic
approaches to enable the formation of nanodispersions of insoluble materials
into a range of liquids. The technology has been used to form nanodispersions
in water, hydrophilic solvents and hydrophobic solvents. For IOTA NanoSolutions,
any liquid has potential to act as a medium for nanodispersion formation
including those that are not conventionally considered as solvents, e.g.
monomers.
The nanodispersions, containing small particles of material (typically 10 – 500nm) scattered evenly throughout the liquid, often exhibit the characteristics of a solution. IOTA NanoSolutions enables the enhanced formulation and performance of the insoluble materials in aqueous environments, addressing many of the issues that constrain effective product development or restrict the wide use of commercial materials.
The nanodispersions, containing small particles of material (typically 10 – 500nm) scattered evenly throughout the liquid, often exhibit the characteristics of a solution. IOTA NanoSolutions enables the enhanced formulation and performance of the insoluble materials in aqueous environments, addressing many of the issues that constrain effective product development or restrict the wide use of commercial materials.
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FAQs
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The IOTA NanoSolutions technologies focus primarily on organic molecules and are based upon a platform involving the formation of a dry, solid blend of insoluble material within a soluble matrix. As well as forming powders, IOTA NanoSolutions has produced tablets and larger structures, all capable of generating nanodispersions. The approach is generic, with over 200 organic materials already successfully dispersed without the need for chemical modification. IOTA NanoSolutions has completed proof-of-principle developments on a number of actives including vitamins and provitamins (e.g. vitamin E acetate), biocides (e.g. azoles, chlorinated phenols, pyretheroids), nutraceuticals (e.g. coenzyme Q10, phytosterols), OTC and Rx pharmaceuticals (e.g. analgesics, lipid therapeutic agents, antihypertensives, hormones), dyes and UV active ingredients (e.g. fluorescers, inkjet, sunscreens, inks), cosmetics, flavours and food additives, bleaches (e.g. per-acids) and surface modifiers.
Soluble matrices are chosen from existing materials and may be selected to comply with food grade, pharmaceutical grade, cGMP or GRAS regulations. IOTA NanoSolutions’ techniques do not require harsh physical or chemical conditions such as aggressive solvents, high temperature, high shear or physical attrition thereby enabling sensitive or low melting point materials to be effectively processed.
The advantages of IOTA NanoSolutions’ nanodispersions depend on the specific requirements of the market and application; however several benefits have already been identified including:
• Ability to increase active ingredient loadings in formulations
• Enhanced material activity including bioactivity/bioavailability
• Increased dispersion and deposition of hydrophobic actives
• Exploitation of new benefits using existing materials
• Expanded palette of ingredients for innovation
• Removal of heat treatment for sensitive materials
Our Technology
Soluble matrices are chosen from existing materials and may be selected to comply with food grade, pharmaceutical grade, cGMP or GRAS regulations. IOTA NanoSolutions’ techniques do not require harsh physical or chemical conditions such as aggressive solvents, high temperature, high shear or physical attrition thereby enabling sensitive or low melting point materials to be effectively processed.
The advantages of IOTA NanoSolutions’ nanodispersions depend on the specific requirements of the market and application; however several benefits have already been identified including:
• Ability to increase active ingredient loadings in formulations
• Enhanced material activity including bioactivity/bioavailability
• Increased dispersion and deposition of hydrophobic actives
• Exploitation of new benefits using existing materials
• Expanded palette of ingredients for innovation
• Removal of heat treatment for sensitive materials